Key result
Premature myocardial infarction accounts for 12.2% of acute MI cases in Türkiye, yet Lp(a) and non-HDL-C were assessed in only 21.2% of 52 submitted young MI cases and family screening in 0%.
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This editorial highlights the growing clinical and public health burden of premature myocardial infarction in young adults, emphasizing the critical need for comprehensive lipid profiling (including Lp(a) and non-HDL-C), investigation of non-atherosclerotic causes and substance use, and early cascade screening of first-degree relatives.
S ome research endeavors begin with a scientific question; others are born from deeply personal experiences.This project began with a loss that profoundly shaped both my life and my professional journey.While preparing for the national medical specialty examination (TUS), long before I had chosen cardiology as my specialty, I lost my brother unexpectedly in his sleep at the age of 38.His sudden death left us with unanswered questions.We never learned what had caused it, nor was our family offered an evaluation for potential inherited cardiovascular risks.Over time, those unanswered questions became a driving force behind my decision to pursue cardiology and my determination to better understand cardiovascular events occurring at a young age.What began as a personal search for answers ultimately evolved into the young myocardial infarction (MI) project and, eventually, this special issue dedicated to understanding and addressing MI in young adults.I share this personal experience because it reflects a reality familiar to every clinician who has cared for a young patient with acute coronary syndrome (ACS): when myocardial infarction (MI) strikes in the third or fourth decade of life, or even earlier, its consequences extend far beyond the coronary arteries.Families may lose a parent, a sibling, or a child; society loses decades of human potential and productivity; and those who survive face a lifetime of cardiovascular risk and secondary prevention, often with limited age-specific evidence to guide their long-term care. What Is the Burden of MI in Young Adults?Premature MI is no longer an uncommon presentation but a growing clinical and public health concern.In the Atherosclerosis Risk in Communities (ARIC) surveillance study, the proportion of MI hospitalizations among patients aged 35-54 years increased from 27% in 1995-1999 to 32% in 2010-2014, with the steepest increase observed among young women. 1 The burden appears to be even greater in Türkiye.In
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Meral Kayıkçıoğlu (2026) conducted an editorial in Premature myocardial infarction. Comprehensive etiological workup, complete lipid profiling (including Lp(a) and non-HDL-C), substance use screening, and family cascade screening vs. Standard clinical practice was evaluated on Reporting of LDL-C and Lp(a)/non-HDL-C in 52 submitted young MI case reports. Premature myocardial infarction accounts for 12.2% of acute MI cases in Türkiye, yet Lp(a) and non-HDL-C were assessed in only 21.2% of 52 submitted young MI cases and family screening in 0%.
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