Key result
Hypertension is linked to ~4-fold higher rates of moderate-to-severe CAD.
Why the study?
The incidence of CAD is twofold higher in hypertensive subjects, and hypertension and CAD share a strong etiological connection. This study aimed to compare coronary angiographic patterns and severity between hypertensive and normotensive patients.
Is hypertension associated with more severe coronary angiographic patterns and higher Gensini scores compared to normotension in patients with coronary artery disease?
Cross-Sectional (n=152)
No
Is hypertension associated with more severe coronary angiographic patterns and higher Gensini scores compared to normotension in patients with coronary artery disease?
In patients undergoing coronary angiography for CAD, hypertension is significantly associated with greater angiographic severity, including higher rates of left main disease, triple vessel disease, proximal lesions, and moderate-to-severe Gensini scores.
Answers are grounded in this paper and cite their sources.
Hypertension-linked severe CAD patterns warrant no practice change yet; leaves open prospective validation of independent prognostic value.
Introduction: Incidence of coronary artery disease (CAD) is twofold higher in hypertensive subjects. According to past clinical trials and observational studies, hypertension and CAD have a strong etiological connection. The aim of the present study was to compare coronary angiographic patterns in hypertensive and normotensive patients. Methods: This cross sectional comparative study was carried out in the inpatient department of cardiology, Mymensingh Medical College Hospital from July 2022 to June 2024. Patients with age >18 years of both sexes with or without hypertension who were admitted for coronary angiogram were included in the study. Patients were classified into two groups: Group A: Hypertensive group and Group B: Normotensive group. Results: Out of 152 patients, 76 patients were in group A (hypertensive) and 76 patients in group B (Normotensive). The mean age of the patients was 52.3±10.5 years in group A (hypertensive) and 52.0±12.0 years in group B (normotensive). Male patients were predominant in both groups, 54(71.1%) in group A and 60(78.9%) in group B. Single vessel disease was significantly lower in group A (26.3% vs 50.0%) and triple vessel disease (28.9% vs 7.9%) & left main disease (28.9% vs 5.3%) were significantly higher in group A than group B (28.9% vs 7.9%). Regarding Gensini score, moderate to severe coronary artery disease (≥36) was significantly higher in group A (hypertensive) than group B (normotensive) (39.5% vs 10.5%; p=0.001). Conclusion: Hypertension has been significantly associated with severity of CAD in terms of complex lesions like left main disease, triple vessels disease and Gensini score (moderate to severe coronary artery disease).
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Halder et al. (2026) conducted a cross-sectional in Coronary artery disease (n=152). Hypertension vs. Normotension was evaluated on Moderate to severe coronary artery disease (Gensini score ≥36) (p=0.001). Hypertension was significantly associated with higher rates of moderate-to-severe CAD (Gensini score ≥36: 39.5% vs 10.5%, p=0.001), triple vessel disease (28.9% vs 7.9%), and left main disease (28.9% vs 5.3%).
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