Key result
Cardiogenic shock occurs in ~10% of STEMI patients in a nationwide Romanian registry.
Why the study?
In-hospital mortality remains high for STEMI patients who develop cardiogenic shock or mechanical complications despite contemporary therapies, and gaps exist regarding the epidemiology, resource use, and prognosis of these complications in an Eastern European setting.
Cohort (n=10,556)
No
This rationale and design paper establishes the largest single-center STEMI registry in Europe evaluating both cardiogenic shock (10.2% incidence) and mechanical complications (2.7% incidence) over a 15-year period in an Eastern European setting.
Answers are grounded in this paper and cite their sources.
Offers contemporary incidence rates of cardiogenic shock and mechanical complications post-STEMI in Eastern Europe; leaves open their prognostic impact pending mortality analyses.
Introduction In-hospital mortality remains high in patients who develop cardiogenic shock or mechanical complications after ST-elevation myocardial infarction (STEMI), despite primary percutaneous coronary intervention, cardiac surgery, vasoactive therapy, and mechanical circulatory support. Aims To present the rationale and design of the ROmanian C.C. Iliescu - ST-Elevation Myocardial Infarction (RO-CCI-STEMI) Registry, established to describe the incidence, baseline characteristics, resource use and prognosis of STEMI patients complicated by cardiogenic shock and/or mechanical complications. Methods The RO-CCI-STEMI Registry is an observational, retrospective, single-centre study of all consecutive STEMI patients from a large tertiary centre in Romania hospitalized during 2011-2025. Data collection was performed from the patient’s electronic health records through an automated process using Python 3. Patients were divided into four mutually exclusive groups. Registry population Of 10556 STEMI patients enrolled, 882 had cardiogenic shock alone, 97 mechanical complications alone, 195 both, and 9382 neither. Formal data analysis is due to be performed. The pre-specified statistical analysis plan is reported within this paper. Conclusion The RO-CCI-STEMI Registry is designed to address gaps in epidemiology, management and prognosis of these complications after STEMI, and serve as a platform for future analyses in a real-world Eastern European setting.
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Filipescu et al. (2026) conducted a cohort in ST-elevation myocardial infarction (STEMI) complicated by cardiogenic shock and/or mechanical complications (n=10,556). Cardiogenic shock (SCAI stages C, D, E) and/or mechanical complications (free-wall rupture, ventricular septal rupture, papillary muscle rupture, pseudoaneurysms) following STEMI vs. STEMI patients with neither cardiogenic shock nor mechanical complications (n=9,382) was evaluated on Incidence of cardiogenic shock or mechanical complications in STEMI and in-hospital mortality of these complications. The RO-CCI-STEMI Registry enrolled 10,556 STEMI patients, recording cardiogenic shock in 10.2% (n=1,077) and mechanical complications in 2.7% (n=292), with formal mortality analyses pending.
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