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November 6, 2026Scandinavian Journal of Rheumatology

Adenosine deaminase-2 (ADA2) enzymatic activity refines interpretation of a heterozygous ADA2 variant in familial Mediterranean fever-associated cutaneous polyarteritis nodosa

Yoichi Nakayama Mirei Shirakashi Kazushi Izawa Y Aida Tsuneo Sasai Ryosuke Hiwa Hideaki Tsuji Shuji Akizuki T Kubo K Tsuji Akihiko Kitoh Hajime Yoshifuji Ran Nakashima M Fujimoto Akio Morinobu

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Abstract

Familial Mediterranean fever (FMF)-associated polyarteritis nodosa (PAN) or cutaneous polyarteritis nodosa (cPAN) and deficiency of adenosine deaminase-2 (DADA2)-related vasculitis can share a medi...

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Nakayama et al. (2026) studied this question.

synapsesocial.com/papers/6af162301865c8158a4d1694 https://doi.org/10.1080/03009742.2026.2738288

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