To Compare the Efficacy of Shigru Taila Nasya with Shadbindhu Taila Nasya in Vataja Pratishyaya -Nasal Eosinophilia- an Open Label Double Arm Controlled Clinical Study

Background: Vataja Pratishyaya is a common nasal disorder characterized by symptoms such as Nasasrava, Nasavarodha, Kshavathu, Nistoda of Shiras, Mukshashosha, Swaropaghata and Nasakandu. These features closely resemble those of nasal eosinophilia, It is characterized by the infiltration of eosinophils, a type of white blood cell involved in allergic responses, into the nasal mucosa. Eosinophils contribute to mucosal inflammation and their presence correlates with disease severity, recurrence and poorer quality of life outcomes. In Allergic rhinitis nasal smear eosinophilia is common noted approximately 60% of patients. It is considered an important marker of allergic rhinitis reflecting changes in the nasal mucosa. Approximately 22% of people suffer from Allergic rhinitis in India Nasya Karma is considered an effective treatment for diseases affecting the nasal region. This study was conducted to compare the efficacy of Shigru Taila Nasya and Shadbindhu Taila Nasya in the management of Vataja Pratishyaya. Methodology: A comparative open-label double-arm controlled clinical study was conducted on 40 subjects diagnosed with Vataja Pratishyaya (Nasal Eosinophilia). The subjects were randomly divided into two groups of 20 each. Group A received Shadbindhu Taila Nasya and Group B received Shigru Taila Nasya for 7 days. Assessment was done on the 8th day and follow-up was carried out on the 15th day. The efficacy of the treatments was evaluated using subjective symptoms, nasal smear eosinophilic count, and TNSS questionnaire scores. Result: The results of the study revealed that both Shigru taila Nasya and Shadbindhu taila Nasya proved beneficial in the management of Vataja Pratishyaya. Shigru taila Nasya demonstrated comparatively better improvement in symptom such as Nasasrava, Nasavarodha, Kshavathu, Nasakandu, Nasal smear eosinophilic count and TNSS questionnaire. Conclusion: The observed therapeutic benefits can be attributed to the Vata- Kapha hara, Srotoshodhaka and Sothahara of the formulations, which helped in expelling the vitiated Kapha, normalize the Vata dosha and improve nasal mucosal health. Thus, both formulations were beneficial, with Shigru taila Nasya showing relatively better efficacy in the management of Vataja Pratishyaya.