Key result
Traumatic limb amputation is linked to increased arterial stiffness and elevated inflammatory markers vs. controls.
Why the study?
The effect of traumatic limb amputation on the development of cardiovascular diseases in young and middle-aged individuals remained poorly understood.
Does traumatic limb amputation increase modifiable cardiovascular risk factors and vascular stiffness parameters in young and middle-aged men compared to individuals without amputations?
Cross-Sectional (n=100)
Does traumatic limb amputation increase modifiable cardiovascular risk factors and vascular stiffness parameters in young and middle-aged men compared to individuals without amputations?
Answers are grounded in this paper and cite their sources.
Young and middle-aged men with traumatic limb amputations exhibit increased vascular stiffness and elevated subclinical inflammatory markers, predisposing them to early atherosclerosis and cardiovascular disease.
BACKGROUND: The effect of traumatic limb amputation on the development of cardiovascular diseases in young and middle-aged individuals remains poorly understood. AIM: To study the effect of traumatic limb amputation on the risk of developing cardiovascular diseases by assessing modifiable risk factors and parameters of vascular stiffness. METHODS: A total of 100 male patients aged 18 to 50 years were examined and divided into three groups: group 1 consisted of 35 patients with traumatic lower limb amputation; group 2 consisted of 35 patients with traumatic upper limb amputation; and group 3 (control group) consisted of 30 patients without amputations. All patients underwent assessment of the main and additional risk factors for cardiovascular diseases, including vascular stiffness parameters, plasma atherogenic index, triglyceride/glucose index, neutrophil-to-lymphocyte ratio, blood leukocyte levels, and C-reactive protein levels. RESULTS: All the main risk factors for the development of cardiovascular diseases (overweight, obesity, smoking, alcohol consumption, insufficient physical activity, unbalanced diet, chronic stress, anxiety, and depression) were identified in patients of groups 1 and 2. Additionally, statistically significant (p 0.001) changes in certain parameters of vascular stiffness were detected. Thus, the mean value of the cardio-ankle vascular index in group 1 was higher than in groups 2 and 3 (8.7 ± 0.9, 7 ± 1, and 6.3 ± 0.7 conventional units, respectively). In addition, statistically significant differences were found in the biological age of blood vessels (50.2 ± 5.3, 43.8 ± 3.2, and 38.5 ± 6.6 years, respectively), blood leukocyte levels (9.3 ± 0.9, 7.3 ± 1.4, and 5.5 ± 0.8 × 10⁹/L, respectively), C-reactive protein (8.5 ± 2.9, 3.6 ± 1.3, and 1.1 ± 0.7 mg/L, respectively), as well as the neutrophil-to-lymphocyte ratio (3.8 ± 0.9, 2.4 ± 0.6, and 1.1 ± 0.2 conventional units, respectively). CONCLUSION: Traumatic limb amputation was found to lead to the development of the main risk factors for cardiovascular diseases, including an increase in subclinical markers of inflammation, which, when combined with vascular stiffness disorders, predispose to the early development of atherosclerosis and cardiovascular diseases, which is particularly important to consider in young and middle-aged individuals.
No takes yet. Share an insight, caveat, or question.
Abazin et al. (2026) conducted a cross-sectional in Traumatic limb amputation (n=100). Traumatic limb amputation (lower limb n=35, upper limb n=35) vs. Control group without amputations (n=30) was evaluated on Cardio-ankle vascular index (CAVI) and modifiable cardiovascular risk factors (p=<0.001). Traumatic lower and upper limb amputations were associated with higher cardio-ankle vascular index (8.7±0.9 and 7±1 vs 6.3±0.7, p<0.001) and elevated inflammatory markers compared to controls.
Synapse has enriched 10 related papers. Consider them for comparative context: