What does this research mean for the field?

During the normal menstrual cycle, serum HDL(2) lipoprotein levels increase significantly at ovulation and decrease as menstruation approaches, while other lipoprotein fractions do not change significantly. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

July 1, 1965Open Access

Fluctuations in Human Serum Lipoproteins During the Normal Menstrual Cycle

MBMurray L. BarclayUnited States Air Force Research Laboratory RBRK BarclayCornell University VSVP SkipskiCornell University

Structured PICO

Do serum lipoproteins fluctuate during the normal menstrual cycle in young women?

Population

11 young women having a similar environment and diet

Intervention

Observation with weekly serum lipoprotein measurements

Outcome

Fluctuations in serum lipoproteins during the normal ovulatory cyclesurrogate

Serum HDL(2) levels fluctuate significantly during the normal menstrual cycle, peaking at ovulation.

Abstract

Lipoproteins were measured in sera from 11 young women having a similar environment and diet. Sera were obtained at weekly intervals over a 12-week period. The values of the lipoproteins during periods in the normal ovulatory cycle were compared to assess their relation to reported hormone concentrations in blood. 2. Only the 4-0s(f) (HDL(2)) (d 1.125 sodium chloride) fraction changed significantly; it increased at ovulation in ten of the 11 subjects and fell as menstruation approached. 3. There was greater variability in most of the low-density rather than the high-density lipoproteins within individuals. The lipoprotein class most characteristic for an individual was the 4-0s(f) or HDL(2) fraction.

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