Ventricular fibrosis was present in 9% (LV) and 38% (RV) of adult survivors of childhood leukemia and was associated with impaired diastolic function, despite no significant myocardial iron overload.
Cross-Sectional (n=58)
In adult survivors of childhood leukemia, ventricular fibrosis is common and associated with diastolic dysfunction, whereas myocardial iron overload is not significant.
BACKGROUND: We sought to assess myocardial iron load and fibrosis, which may potentially affect cardiac function, in adult survivors of childhood leukemias and their relationships with left (LV) and right ventricular (RV) function. PROCEDURE: Fifty-eight (33 males) adult survivors, aged 24.5 ± 4.4, underwent cardiac magnetic resonance (CMR) at 16.6 ± 5.8 years after completion of treatment. Myocardial iron load and fibrosis were quantified using respectively T2* scan and late gadolinium enhancement. Right and left ventricular ejection fraction (EF) was measured by CMR, while myocardial function was assessed using tissue Doppler imaging. RESULTS: None of the survivors had significant myocardial iron overload (T2* 0.05). CONCLUSION: Ventricular fibrosis may occur in long term survivors of childhood leukemias and is related to diastolic function in the absence of significant myocardial iron overload.
Cheung et al. (Sat,) conducted a cross-sectional in Adult survivors of childhood leukemias (n=58). Ventricular fibrosis was present in 9% (LV) and 38% (RV) of adult survivors of childhood leukemia and was associated with impaired diastolic function, despite no significant myocardial iron overload.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: