Systemic Lupus Erythematosus: Recent Advances in Its Diagnosis and Treatment

Article1 August 1956SYSTEMIC LUPUS ERYTHEMATOSUS: RECENT ADVANCES IN ITS DIAGNOSIS AND TREATMENTEDMUND L. DUBOIS, M.D., F.A.C.P.EDMUND L. DUBOIS, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-45-2-163 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the last six years the author has had the opportunity personally to study and treat 175 patients with systemic lupus erythematosus. The purpose of this paper is to review the current status (to January, 1956) of 163 of these patients, who have adequate records available, in order to determine the following:1. The incidence of the disease in a 3,600 bed hospital before and after the frequent use of the L.E. cell test.2. The course of the disease with particular reference to spontaneous remissions.3. The value of a battery of different types of L.E. cell tests.4....Bibliography1. HargravesRichmondMorton MMHR: Presentation of two bone marrow elements: the "tart" cell and the "L.E." cell, Proc. Staff Meet., Mayo Clin. 23: 25, 1948. MedlineGoogle Scholar2. Dubois EL: Simplified method for the L.E. cell test, Arch. Int. Med. 92: 168, 1953. CrossrefGoogle Scholar3. Dubois EL: The effect of the L.E. cell test on the clinical picture of systemic lupus erythematosus, Ann. Int. Med. 38: 1265, 1953. LinkGoogle Scholar4. HarveyShulmanTumultyConleySchoenrich AMLEPACLEH: Systemic lupus erythematosus: review of the literature and clinical analysis of 138 cases, Medicine 33: 291, 1954. CrossrefMedlineGoogle Scholar5. MerrellShulman MLE: Determination of prognosis in chronic disease illustrated by systemic lupus erythematosus, J. Chron. Dis. 1: 12, 1955. CrossrefMedlineGoogle Scholar6. MooreLutz JEWB: The natural history of systemic lupus erythematosus: an approach to its study through chronic biologic false positive reactors, J. Chron. Dis. 1: 297, 1955. CrossrefMedlineGoogle Scholar7. Dubois EL: Discoid lupus erythematosus: an analysis of its systemic manifestations, Ann. Int. Med. 44: 482-496 (Mar.) 1956. LinkGoogle Scholar8. Ben-Asher S: Recurrent acute lupus erythematosus disseminatus: report of a case which has survived 23 years after the onset of systemic manifestations, Ann. Int. Med. 34: 243, 1951. LinkGoogle Scholar9. WeissSwift RSS: The significance of a positive L.E. phenomenon, Arch. Dermat. and Syph. 72: 103, 1955. CrossrefGoogle Scholar10. ZimmerHargraves FEMM: The effect of blood coagulation on L.E. cell formation, Proc. Staff Meet., Mayo Clin. 27: 424, 1952. MedlineGoogle Scholar11. SnapperNathan IDJ: The mechanics of the L.E. cell phenomenon, studied with a simplified test, Blood 10: 718, 1955. CrossrefMedlineGoogle Scholar12. Prokoptchouk AJ: Traitement du lupus erythemateus par l'acriquine, Vestnik. venerol. dermat. 2/3: 23, 1940. Abstracted, Yearbook of Dermatology and Syphilology, 1952, edited by M. B. Sulzberger and R. L. Baer, Chicago. Year Book Publishers, Inc., 1953, p. 92. Google Scholar13. Page F: Treatment of lupus erythematosus with Mepacrine, Lancet 2: 755, 1951. CrossrefMedlineGoogle Scholar14. Dubois EL: Quinacrine (Atabrine) in treatment of systemic and discoid lupus erythematosus, Arch. Int. Med. 94: 131, 1954. CrossrefGoogle Scholar15. LeeperAllende RWMF: Antimalarials in the treatment of discoid lupus erythematosus, Arch. Dermat. and Syph. 73: 50, 1956. CrossrefGoogle Scholar16. DuboisCommonsStarrSteinMorrison ELRRPCSR: Corticotropin and cortisone treatment for systemic lupus erythematosus, J. A. M. A. 149: 995, 1952. CrossrefMedlineGoogle Scholar17. Dubois EL: Prednisone and prednisolone in the treatment of systemic lupus erythematosus, J. A. M. A. 161: 427 (June 2) 1956. CrossrefMedlineGoogle Scholar18. ChasisGoldringBaldwin HWDS: Effect of febrile plasma, typhoid vaccine and nitrogen mustard on renal manifestations of human glomerulonephritis, Proc. Soc. Exper. Biol. and Med. 71: 565, 1949. CrossrefMedlineGoogle Scholar19. DustanCorcoranHaserick HPACJR: Urinary sediment in acute diffuse lupus erythematosus: nature and response to treatment, read before the National Meeting of the American Federation for Clinical Research, Atlantic City, N. J., May, 1951. Google Scholar20. Dubois EL: Nitrogen mustard in treatment of systemic lupus erythematosus, Arch. Int. Med. 93: 667, 1954. CrossrefGoogle Scholar21. JessarLamont-HaversRagan RARWC: Natural history of lupus erythematosus disseminatus, Ann. Int. Med. 38: 717, 1953. LinkGoogle Scholar22. Finney DJ: Probit analysis. A statistical treatment of the sigmoid response curve, 1947, Cambridge University Press, New York. Google Scholar23. ZinkhamConley WHCL: Some factors influencing the formation of L.E. cells, Bull. Johns Hopkins Hosp. 98: 102 (Feb.) 1956. MedlineGoogle Scholar24. Kurnick NB: A rational therapy of systemic lupus erythematosus, Arch. Int. Med. 97: 562 (May) 1956. CrossrefGoogle Scholar25. MullinsWattsWilson JFFLCJ: Plaquenil in the treatment of lupus erythematosus J. A. M. A. 161: 879 (June 30) 1956. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Los Angeles, California*Presented at the Thirty-seventh Annual Session of The American College of Physicians, Los Angeles, California, April 16, 1956.From the Department of Medicine, University of Southern California School of Medicine, and the Los Angeles County General Hospital.The steroids used in this study were generously supplied by Dr. Elmer Alpert, of Merck & Company, Inc.Atabrine and chloroquine were contributed by Dr. J. B. Rice, of Winthrop-Stearns, Inc. Amodiaquin and its placebo were given us by Dr. E. H. Payne, Parke Davis & Company.Requests for reprints should be addressed to Edmund L. Dubois, M.D., Assistant Clinical Professor of Medicine, University of Southern California School of Medicine, Los Angeles, California. 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FRIOU, M.D.Observations on the course and treatment of systemic lupus erythematosusTHE CLINICAL FEATURES, PATHOGENESIS AND THERAPY OF SYSTEMIC LUPUS ERYTHEMATOSUSClinical and histologic spectrum of the nephrotic syndromeVeränderungen des Zentralnervensystems bei Krankheiten und abnormen Pigmentationen der HautThe Manifestations of Collagen Diseases: With Special Reference to Systemic Lupus Erythematosus and Polyarteritis NodosaFAMILIAL HYPERGAMMAGLOBULINÆMIA AND SYSTEMIC LUPUS ERYTHEMATOSUSENDOBRONCHIAL TUBERCULOSIS IN CHILDRENSOME EFFECTS OF HIGH ALTITUDE ON MANMEPACRINE v. CHLOROQUINEThe Way We LimpControl of Systemic Lupus Erythematosus 1 August 1956Volume 45, Issue 2Page: 163-184KeywordsAntimalarialsArthritisBlood cellsChloroquineHospital medicineLupus erythematosusSteroid therapySteroidsToxicologyWhite blood cells ePublished: 1 December 2008 Issue Published: 1 August 1956 Copyright & PermissionsCopyright ©, 1956, by The American College of PhysiciansPDF downloadLoading ...