Serum high-sensitivity cardiac troponin T levels were significantly higher in patients with infiltrative cardiomyopathy compared to those with hypertrophic cardiomyopathy (0.083 vs 0.027 ng/ml, p<0.001).
Case-Control (n=46)
No
Does high-sensitivity cardiac troponin T (hs-cTnT) accurately differentiate infiltrative cardiomyopathy from hypertrophic cardiomyopathy?
High-sensitivity cardiac troponin T (hs-cTnT) is a highly accurate biomarker (AUC 0.939) for distinguishing infiltrative cardiomyopathies, such as cardiac amyloidosis and Fabry disease, from hypertrophic cardiomyopathy.
Effect estimate: AUC 0.939
Absolute Event Rate: 0.083% vs 0.027%
p-value: p=<0.001
BACKGROUND: Because infiltrative cardiomyopathy and hypertrophic cardiomyopathy (HCM) share clinical and hemodynamic features of left ventricular (LV) hypertrophy and abnormal diastolic function, it is often difficult to distinguish these entities. METHODS: We investigated the potential role of high-sensitivity cardiac troponin T (hs-cTnT) for differentiation of infiltrative cardiomyopathy from HCM. RESULTS: The study group consisted of 46 consecutive patients with infiltrative cardiomyopathies or HCM in whom sarcomere protein gene mutations were identified at Kochi Medical School Hospital; of these, there were 11 patients with infiltrative cardiomyopathy (cardiac amyloidosis in 8 patients and Fabry disease in 3 patients) and 35 HCM patients. Serum hs-cTnT level was significantly higher in patients who had infiltrative cardiomyopathy than in those who had HCM (0.083 ± 0.057 ng/ml versus 0.027 ± 0.034 ng/ml, p 40 years at age), hs-cTnT level, maximum LV wall thickness, posterior wall thickness, peak early (E) transmitral filling velocity, peak early diastolic (Ea) velocity of tissue Doppler imaging at the lateral corner and E/Ea ratios at both the septal and lateral corners were significantly different between the two groups. As for diagnostic accuracy to differentiate the two groups by using receiver operating characteristic analysis, hs-cTnT was the highest value of area under the curve (0.939) and E/Ea (lateral) was second highest value (0.914). CONCLUSIONS: Serum hs-cTnT is a helpful diagnostic indicator for accurate differentiation between infiltrative cardiomyopathy and HCM.
Kubo et al. (Mon,) conducted a case-control in Infiltrative cardiomyopathy and hypertrophic cardiomyopathy (n=46). Infiltrative cardiomyopathy vs. Hypertrophic cardiomyopathy was evaluated on Serum high-sensitivity cardiac troponin T (hs-cTnT) level in ng/ml (AUC 0.939, p=<0.001). Serum high-sensitivity cardiac troponin T levels were significantly higher in patients with infiltrative cardiomyopathy compared to those with hypertrophic cardiomyopathy (0.083 vs 0.027 ng/ml, p<0.001).
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