Analysis of rat sarcomeric myosin heavy chain genes revealed tissue-specific and developmentally regulated expression, with non-conserved intervening sequences.
Myosin heavy chain is encoded by a large multigene family. Using pMHC-25, a recombinant cDNA clone isolated from the rat myogenic cell line L6E9, four members of this family in the rat have been isolated and shown to be tissue-specific and developmentally regulated. The coding regions of these genes share regions of homology interspaced with regions of non-homology. Detailed analysis of one embryonic and one adult myosin heavy chain gene shows that the coding sequences are interrupted by numerous intervening sequences whose number, size, and distribution do not appear to be conserved in the same organism or between species.
Wydro et al. (Sat,) reported a other. Analysis of rat sarcomeric myosin heavy chain genes revealed tissue-specific and developmentally regulated expression, with non-conserved intervening sequences.
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