November 1, 1986
View Full PaperCan beta blockers limit myocardial infarct size?
Key Result
Beta blockers reduce mortality and have undisputed clinical value, though it remains questionable whether these benefits are explained by or require myocardial infarct size limitation.
Structured PICO
Do beta blockers limit myocardial infarct size?
I
Intervention
Beta blockers
O
Outcome
Myocardial infarct size
This paper questions the mechanistic assumption that beta blockers reduce mortality post-MI primarily by limiting infarct size.
Main Result
Absolute Event Rate: 0% vs 0%
Abstract
The suggestion that beta blockers can reduce mortality is not in dispute, nor is the undoubted clinical value of this important group of drugs. What must however be questioned is whether these beneficial effects can be, or need be, explained by 'infarct size limitation'.