Key result
Beta blockers reduce mortality and have undisputed clinical value, though it remains questionable whether these benefits are explained by or require myocardial infarct size limitation.
Why the study?
Do beta blockers limit myocardial infarct size?
Do beta blockers limit myocardial infarct size?
Answers are grounded in this paper and cite their sources.
This paper questions the mechanistic assumption that beta blockers reduce mortality post-MI primarily by limiting infarct size.
The suggestion that beta blockers can reduce mortality is not in dispute, nor is the undoubted clinical value of this important group of drugs. What must however be questioned is whether these beneficial effects can be, or need be, explained by 'infarct size limitation'.
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Hearse et al. (1986) studied this question. Beta blockers reduce mortality and have undisputed clinical value, though it remains questionable whether these benefits are explained by or require myocardial infarct size limitation.
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