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January 12, 1981Acta Medica Scandinavica

Beta Blockade and the Secondary Prevention of Myocardial Infarction

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Why the study?

Do beta blockers reduce mortality in patients following myocardial infarction?

Population

Patients following myocardial infarction

Comparison

Beta blockers vs Control/placebo

Design

Review

Authors

JHJ R HamptonWestern University

Discussion

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Implication

Early post-MI beta-blocker data insufficient to confirm mortality benefit; leaves open need for larger definitive RCTs.

Structured PICO

Do beta blockers reduce mortality in patients following myocardial infarction?

P
Population
Patients following myocardial infarction
I
Intervention
Beta blockers (including propranolol, practolol, and alprenolol)
C
Comparator
Control/placebo (in the context of the reviewed trials)
O
Outcome
Mortalityhard clinical

This historical review highlights that early trials of beta blockers for secondary prevention of MI did not demonstrate a statistically significant reduction in mortality by intention-to-treat analysis, emphasizing the need for larger, well-designed trials.

Limitations

  • Lack of data in published trials
  • Failure to agree on a common method of presenting results
  • Disagreement on intention-to-treat versus clinical effectiveness analysis
  • Small sample sizes in some trials

Cite This Study

J R Hampton (1981) studied this question.

synapsesocial.com/papers/6a70f21b35aa2c282ce24629https://doi.org/10.1111/j.0954-6820.1981.tb03660.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Randomised trial comparing propranolol with atenolol in immediate treatment of suspected myocardial infarction.1980 · 150 citations
  2. 2Improvement in prognosis of myocardial infarction by long-term beta-adrenoreceptor blockade using practolol. A multicentre international study.1975 · 301 citations
  3. 3Effect of beta-blockers on arrhythmias during six weeks after suspected myocardial infarction1979 · 36 citations
  4. 4PRACTOLOL IN ACUTE MYOCARDIAL INFARCTION1976 · 121 citations
  5. 5Multicentre post-infarction trial of propranolol in 49 hospitals in the United Kingdom, Italy, and Yugoslavia.1980 · 165 citations