Why the study?
Do beta-adrenergic blockers prevent the fracture of vulnerable atherosclerotic plaques in survivors of myocardial infarction?
Do beta-adrenergic blockers prevent the fracture of vulnerable atherosclerotic plaques in survivors of myocardial infarction?
This paper proposes a theoretical mechanism suggesting that beta-blockers protect MI survivors by preventing the fracture of vulnerable atherosclerotic plaques.
Does not support changing beta-blocker use post-MI; leaves open the plaque-fracture hypothesis for prospective testing.
Beta-adrenergic blockers have a protective effect in reducing mortality in survivors of myocardial infarction. It is proposed that, in addition to their effects in reducing heart rate, blood pressure, myocardial contractility and ventricular ectopy, beta-blockers may prevent or attenuate the fracture of vulnerable atherosclerotic plaques and thereby reduce coronary thrombosis, myocardial infarction and sudden cardiac death.
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William H. Frishman (1991) studied this question.
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