Synthetic peptides derived from conserved regions of the amino-terminal part of VP1 identified nine group-common linear epitopes recognized by sera from patients with enterovirus infections.
Synthetic peptides from conserved regions of enterovirus VP1 may be useful for developing broad-range serological diagnostic tests.
Synthetic peptides were employed in enzyme-linked immunosorbent assays to identify group-common linear epitopes in the structural and nonstructural proteins of enteroviruses. Nine linear epitopes were recognized by using sera from patients with heterotypic immunoglobulin G antibody responses to enterovirus infections. The most-reactive peptides were derived from conserved regions of the amino-terminal part of VP1, whereas peptides representing sequences from other conserved regions of VP1, as well as VP2, VP3, and VP4, and from a nonstructural region showed no or poor reactivity. These findings may be useful in the development of serological tests for the diagnosis of infections caused by a broad range of enteroviruses.
Cello et al. (Thu,) conducted a other in Enterovirus infections. Synthetic peptides in enzyme-linked immunosorbent assays was evaluated on Identification of group-common linear epitopes. Synthetic peptides derived from conserved regions of the amino-terminal part of VP1 identified nine group-common linear epitopes recognized by sera from patients with enterovirus infections.