A single 2.5-mg dose of oral vitamin K significantly reduced the mean time to reach a therapeutic INR compared to withholding warfarin (1.4 vs 2.3 days; p=0.001).
Observational (n=28)
No
Does a single 2.5-mg dose of oral vitamin K reduce the time to therapeutic INR compared to withholding warfarin in excessively anticoagulated men without bleeding complications?
Administration of 2.5 mg oral vitamin K significantly reduces the time to reach a therapeutic INR compared to simply withholding warfarin in overanticoagulated patients.
Absolute Event Rate: 1.4% vs 2.3%
p-value: p=0.001
STUDY OBJECTIVE: To compare withholding warfarin therapy with low-dose (2.5 mg) oral vitamin K therapy in excessively anticoagulated patients without bleeding complications. DESIGN: Prospective and retrospective studies. SETTING: Anticoagulation clinic at a Veterans Affairs institution. PATIENTS: Twenty-eight men were matched according to initial international normalized ratio (INR) and INR goal ranges. INTERVENTIONS: The retrospective arm of the study consisted of chart reviews of overanticoagulated patients whose warfarin doses were held until therapeutic INR values were reached. The prospective arm included overanticoagulated patients who were administered a single 2.5-mg dose of oral vitamin K. MEASUREMENTS AND MAIN RESULTS: Mean days to therapeutic INR values were 2.3+/-0.6 and 1.4+/-0.6 (p=0.001), and mean reduction in INR 1 day after treatment intervention was 1.32+/-0.79 and 3.46+/-1.31 (p<001) U for the withholding and vitamin K groups, respectively. CONCLUSION: Compared with withholding the warfarin dose, administration of 2.5 mg of oral vitamin K to excessively anticoagulated patients receiving warfarin significantly reduced the time required to reach a therapeutic INR as well as final INR.
Duong et al. (Thu,) conducted a observational in Excessive anticoagulation without bleeding complications (n=28). Oral vitamin K vs. Withholding warfarin therapy was evaluated on Mean days to therapeutic INR values (p=0.001). A single 2.5-mg dose of oral vitamin K significantly reduced the mean time to reach a therapeutic INR compared to withholding warfarin (1.4 vs 2.3 days; p=0.001).