Why the study?
Does a single 2.5-mg dose of oral vitamin K reduce the time to therapeutic INR compared to withholding warfarin in excessively anticoagulated men without bleeding complications?
Observational (n=28)
No
Does a single 2.5-mg dose of oral vitamin K reduce the time to therapeutic INR compared to withholding warfarin in excessively anticoagulated men without bleeding complications?
Administration of 2.5 mg oral vitamin K significantly reduces the time to reach a therapeutic INR compared to simply withholding warfarin in overanticoagulated patients.
Answers are grounded in this paper and cite their sources.
Low-dose vitamin K may hasten INR correction in overanticoagulated patients without bleeding; leaves open whether it improves outcomes versus withholding alone.
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Duong et al. (1998) conducted an observational in Excessive anticoagulation without bleeding complications (n=28). Oral vitamin K vs. Withholding warfarin therapy was evaluated on Mean days to therapeutic INR values (p=0.001).
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