March 1, 2008
View Full PaperTardive dyskinesia and new antipsychotics
Structured PICO
Do second-generation antipsychotics reduce tardive dyskinesia risk compared to first-generation antipsychotics?
I
Intervention
Second-generation antipsychotics
C
Comparator
First-generation antipsychotics
O
Outcome
Tardive dyskinesia risksafety
Second-generation antipsychotics carry a lower risk of tardive dyskinesia than first-generation agents, though the risk remains clinically relevant.
Abstract
Current evidence supports a lower tardive dyskinesia risk for second-generation antipsychotics than for first-generation antipsychotics. Tardive dyskinesia incidence was higher with second-generation antipsychotics than previously reported, possibly due to recent studies with relatively short mean durations and use of nonstandard tardive dyskinesia definitions.