HEV-C sequences present in the Madagascar cVDPV isolate contribute to its characteristics, including pathogenicity, suggesting interspecific recombination favors cVDPV emergence.
Interspecific recombination with HEV-C sequences contributes to the pathogenicity and phenotypic biodiversity of vaccine-derived polioviruses.
Pathogenic circulating vaccine-derived polioviruses (cVDPVs) have become a major obstacle to the successful completion of the global polio eradication program. Most cVDPVs are recombinant between the oral poliovirus vaccine (OPV) and human enterovirus species C (HEV-C). To study the role of HEV-C sequences in the phenotype of cVDPVs, we generated a series of recombinants between a Madagascar cVDPV isolate and its parental OPV type 2 strain. Results indicated that the HEV-C sequences present in this cVDPV contribute to its characteristics, including pathogenicity, suggesting that interspecific recombination contributes to the phenotypic biodiversity of polioviruses and may favor the emergence of cVDPVs.
Riquet et al. (Thu,) conducted a other in Circulating vaccine-derived polioviruses (cVDPVs). HEV-C sequences in cVDPV recombinants vs. Parental OPV type 2 strain was evaluated on Phenotype and pathogenicity characteristics. HEV-C sequences present in the Madagascar cVDPV isolate contribute to its characteristics, including pathogenicity, suggesting interspecific recombination favors cVDPV emergence.