Key result
HEV-C sequences present in the Madagascar cVDPV isolate contribute to its characteristics, including pathogenicity, suggesting interspecific recombination favors cVDPV emergence.
Interspecific recombination with HEV-C sequences contributes to the pathogenicity and phenotypic biodiversity of vaccine-derived polioviruses.
Warrants enhanced genomic surveillance for recombinant cVDPVs; leaves open generalizability of recombination-driven emergence beyond this isolate.
Pathogenic circulating vaccine-derived polioviruses (cVDPVs) have become a major obstacle to the successful completion of the global polio eradication program. Most cVDPVs are recombinant between the oral poliovirus vaccine (OPV) and human enterovirus species C (HEV-C). To study the role of HEV-C sequences in the phenotype of cVDPVs, we generated a series of recombinants between a Madagascar cVDPV isolate and its parental OPV type 2 strain. Results indicated that the HEV-C sequences present in this cVDPV contribute to its characteristics, including pathogenicity, suggesting that interspecific recombination contributes to the phenotypic biodiversity of polioviruses and may favor the emergence of cVDPVs.
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Riquet et al. (2008) studied Circulating vaccine-derived polioviruses (cVDPVs). HEV-C sequences in cVDPV recombinants vs. Parental OPV type 2 strain was evaluated on Phenotype and pathogenicity characteristics. HEV-C sequences present in the Madagascar cVDPV isolate contribute to its characteristics, including pathogenicity, suggesting interspecific recombination favors cVDPV emergence.
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