The provided text is a list of editorial board members and does not contain clinical trial data.
Do antioxidants and methionine alter the effects of platelet-activating factor on cardiovascular function and oxidative stress markers in anesthetized dogs?
Platelet-activating factor (PAF) is released in numerous clinical situations. PAF primes or directly activates polymorphonuclear (PMN) leukocytes, which results in release of oxyradicals (O− 2, H2O2, .OH) and hypochlorous acid (HOCl). The authors investigated the effects of PAF (1 μg/kg IV) in the absence and in the presence of antioxidants (superoxide dismutase SOD, catalase CAT, dimethylthiourea DMTU) and methionine, a quencher of HOCl, on cardiac function and contractility; blood lactate, gases, and pH levels; serum creatine kinase activity (CK); chemiluminescent activity of PMN leukocytes; and cardiac tissue malondialdehyde (MDA) in anesthetized dogs. Hemodynamic measurements and collection of blood samples for various biochemical measurements were made before and at various intervals up to two hours after PAF administration in the presence and absence of various antioxidants.
Prasad et al. (Thu,) reported a other. The provided text is a list of editorial board members and does not contain clinical trial data.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: