Key points are not available for this paper at this time.
Evidence is presented for the facile acid‐hydrolytic cleavage of C ‐terminal N ‐alkylated amino acid residues in peptide acids. A mechanism (defined as “back‐biting”) is proposed in which the process is initiated by a nucleophilic attack of the conjugated base of the terminal acid on the (protonated) preceding cis ‐peptide bond.
Auwera et al. (Mon,) studied this question.