Confidence Intervals Extract Clinically Useful Information from Data

Editorials1 February 1988Confidence Intervals Extract Clinically Useful Information from DataLEONARD E. BRAITMAN, Ph.D.LEONARD E. BRAITMAN, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-2-296 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA paper reporting a trial of a new treatment or diagnostic test is difficult to interpret when its conclusions are based on a small number of subjects. The statistical descriptors known as confidence intervals can increase the ability of readers to evaluate conclusions drawn from small trials. Fortunately, an increasing number of journals are asking authors to add confidence intervals to the reporting of data in their papers (1-9).Most clinical studies are necessarily based on a sample (a group of patients or experimental subjects) thought to be reasonably representative of the entire population of patients or of the subjects...References1. BAILARMOSTELLER JF. Guidelines for statistical reporting in articles for medical journals: amplifications and explanations. Ann Intern Med. 1988;108:266-73. LinkGoogle Scholar2. SIMON R. Confidence intervals for reporting results of clinical trials. Ann Intern Med. 1986;105:429-35. LinkGoogle Scholar3. ROTHMAN K. Significance questing Editorial. Ann Intern Med. 1986;105:445-7. LinkGoogle Scholar4. FREIMANCHALMERSSMITHKUEBLER JTHR. The importance of beta, the type II error and sample size in the design and interpretation of the randomized control trial: survey of 71 "negative" trials. N Engl J Med. 1978;299:690-4. CrossrefMedlineGoogle Scholar5. ROTHMAN K. A show of confidence Letter. N Engl J Med. 1978;299:1362-3. CrossrefMedlineGoogle Scholar6. GORE S. Statistics in question: assessing methods-confidence intervals. Br Med J Clin Res. 1981;283:660-2. CrossrefMedlineGoogle Scholar7. GARDNERALTMAN MD. Confidence intervals rather than P values: estimation rather than hypothesis testing. Br Med J Clin Res. 1986;292:746-50. CrossrefMedlineGoogle Scholar8. BERRY G. Statistical significance and confidence intervals Editorial. Med J Aust. 1986;144:618-9. CrossrefMedlineGoogle Scholar9. BULPITT C. Confidence intervals. Lancet. 1987;1:494-7. CrossrefMedlineGoogle Scholar10. HAINSWORTHGROSHBURNETTJONESWOLFFGRECO JWLHSF. Advanced ovarian cancer: long term results of treatment with intensive cisplatin-based chemotherapy of brief duration. Ann Intern Med. 1988;108:165-70. LinkGoogle Scholar11. FLETCHERFLETCHERWAGNER RSE. Clinical Epidemiology: The Essentials. Baltimore: William 1982. Google Scholar12. LENTNERLENTNERWINK CCA, eds. Geigy Scientific Tables, vol. 2. 8th ed. West Caldwell, New Jersey: CIBA-Geigy; 1982:89-102. Google Scholar13. ROTHMAN K. Modern Epidemiology. Boston: Little, Brown 1986:115-29. Google Scholar14. HANLEYLIPPMAN-HAND JA. If nothing goes wrong, is everything all right? Interpreting zero denominators. JAMA. 1983;249:1743-5. CrossrefMedlineGoogle Scholar15. CRAWFORDBOWDENHACKMANGLEAVESMEYERSCLARK SRRCJJ. Rapid detection of cytomegalovirus pulmonary infection by bronchoalveolar lavage and centifugation culture. Ann Intern Med. 1988;108:180-5. LinkGoogle Scholar16. HOROWITZERSHLERMCKINNEYBATTIOLA MWPR. Duration of immunity after Hepatitis B vaccination: efficacy of low-dose booster vaccine. Ann Intern Med. 1988;108:185-9. LinkGoogle Scholar17. MURPHY E. A Companion to Medical Statistics. Baltimore: Johns Hopkins Univ. Press; 1985:102-5. Google Scholar18. COLQUHOUN D. Lectures on Biostatistics An Introduction to Statistics with Applications in Biology and Medicine. Oxford: Clarendon; 1971:101-5. Google Scholar19. WONNACOTTWONNACOTT RT. Introductory Statistics. 4th ed. New York: John Wiley 1985:222-4. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. 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HUTH, M.D. 1 February 1988Volume 108, Issue 2Page: 296-298KeywordsBiostatisticsConfidence intervalsInformation retrievalPatient advocacyResearch design Issue Published: 1 February 1988 PDF downloadLoading ...