What does this research mean for the field?

Nonsteroidal anti-inflammatory drug (NSAID) use is strongly associated with acute nonvariceal upper gastrointestinal tract bleeding, particularly in older patients and within the first three months of starting therapy. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 1, 1986

Nonsteroidal Anti-inflammatory Drugs and Gastrointestinal Bleeding

Structured PICO

Does NSAID use increase the risk of acute nonvariceal upper gastrointestinal tract bleeding?

Population

57 consecutive patients presenting to hospital with acute nonvariceal upper gastrointestinal tract bleeding (AUGIB) and 123 sex- and age-matched controls (total n=180)

Intervention

Nonsteroidal anti-inflammatory drug (NSAID) use

Comparator

No NSAID use

Outcome

Acute nonvariceal upper gastrointestinal tract bleeding (AUGIB)safety

NSAID use is significantly more common in patients presenting with acute nonvariceal upper gastrointestinal tract bleeding compared to matched controls.

Abstract

This study looked at the association between nonsteroidal anti-inflammatory drug (NSAID) use and acute nonvariceal upper gastrointestinal tract bleeding (AUGIB). Fifty-seven consecutive patients presenting to hospital with AUGIB were compared with 123 sex- and age-matched controls. Twenty-four (42.1%) of the 57 AUGIB patients were taking NSAIDs compared with 23 (18.1%) of the 123 control subjects. Patients whose AUGIB was associated with NSAID use were significantly older than the group whose bleeding was not associated with drug use; no other differences between these two groups was found. Seventy percent of patients taking nonacetylsalicylic acid who developed bleeding in this study did so within three months of starting therapy. Abdominal pain was an infrequent presenting complaint.

Mark Helpful

Bookmark

Relay