What does this research mean for the field?

Nonsteroidal anti-inflammatory drug (NSAID) use is strongly associated with acute nonvariceal upper gastrointestinal tract bleeding, particularly in older patients and within the first three months of starting therapy. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 1, 1986Archives of Internal Medicine

Nonsteroidal Anti-inflammatory Drugs and Gastrointestinal Bleeding

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Why the study?

Does NSAID use increase the risk of acute nonvariceal upper gastrointestinal tract bleeding?

Structured PICO

Does NSAID use increase the risk of acute nonvariceal upper gastrointestinal tract bleeding?

Population

57 consecutive patients presenting to hospital with acute nonvariceal upper gastrointestinal tract bleeding (AUGIB) and 123 sex- and age-matched controls (total n=180)

Intervention

Nonsteroidal anti-inflammatory drug (NSAID) use

Comparator

No NSAID use

Outcome

Acute nonvariceal upper gastrointestinal tract bleeding (AUGIB)safety

NSAID use is significantly more common in patients presenting with acute nonvariceal upper gastrointestinal tract bleeding compared to matched controls.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

NSAID use was associated with AUGIB; leaves open whether this warrants prescribing changes pending prospective confirmation.

Cite This Study

William R. Bartle (1986) studied this question.

synapsesocial.com/papers/6a15fb0ccaf7e3ea0ee3eea6 https://doi.org/10.1001/archinte.1986.00360240087015

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Nonsteroidal Anti-inflammatory Drugs and Gastrointestinal Bleeding

Structured PICO

Discussion

Implication

Cite This Study

Nonsteroidal Anti-inflammatory Drugs and Gastrointestinal Bleeding

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider