Key result
Use of non-steroidal anti-inflammatory drugs (NSAIDs) was significantly associated with upper gastrointestinal bleeding (OR 7.4; 95% CI 3.7 to 14.7; p<0.001), as was aspirin use (OR 2.2).
Why the study?
Does the use of NSAIDs or aspirin increase the risk of upper gastrointestinal bleeding?
Population
161 patients with upper gastrointestinal bleeding from 'erosive lesions' and hospital control subjects…
Comparison
Use of non-steroidal anti-inflammatory drugs or… vs Hospital control subjects matched for age and sex
Design
Case-control
Authors
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May warrant GI risk caution with NSAIDs or aspirin; leaves open prospective confirmation of these associations.
Case-Control
Yes
Does the use of NSAIDs or aspirin increase the risk of upper gastrointestinal bleeding?
Effect estimate: OR 7.4 (95% CI 3.7 to 14.7)
p-value: p=<0.001
The use of NSAIDs and aspirin is significantly associated with an increased risk of upper gastrointestinal bleeding from erosive lesions.
Holvoet et al. (1991) conducted a case-control in Upper gastrointestinal bleeding. Non-steroidal anti-inflammatory drugs (NSAIDs) and aspirin vs. Hospital control subjects was evaluated on Upper gastrointestinal bleeding from erosive lesions (OR 7.4, 95% CI 3.7 to 14.7, p=<0.001). Use of non-steroidal anti-inflammatory drugs (NSAIDs) was significantly associated with upper gastrointestinal bleeding (OR 7.4; 95% CI 3.7 to 14.7; p<0.001), as was aspirin use (OR 2.2).
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