Why the study?
Does the use of aspirin and other nonnarcotic analgesics increase the risk of a first episode of major upper gastrointestinal tract bleeding?
Population
Subjects in a hospital-based case-control study assessed for a first episode of major upper gastrointestinal…
Comparison
Aspirin and other nonnarcotic analgesics used… vs Non-use or discontinued use of aspirin and other…
Design
Case-control
Authors
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Aspirin use warrants clinical caution for GI bleeding risk; supports association in case-control data but leaves causality open.
Does the use of aspirin and other nonnarcotic analgesics increase the risk of a first episode of major upper gastrointestinal tract bleeding?
Aspirin use, even occasionally, substantially increases the risk of major upper gastrointestinal bleeding.
Micha Levy (1988) studied this question.
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