September 1, 2000The American Journal of Gastroenterology
Risk of upper gastrointestinal bleeding associated with use of low-dose aspirin
Key result
Low-dose aspirin use was associated with an increased risk of hospitalization for upper gastrointestinal bleeding compared to the general population (SIRR 2.6; 95% CI 2.2-2.9).
Why the study?
Does low-dose aspirin increase the risk of hospitalization for upper gastrointestinal bleeding compared to the general population?
Population
27,694 users of low-dose aspirin in North Jutland County, Denmark
Comparison
Low-dose aspirin vs General population in the county
Design
Cohort
Follow-up
January 1, 1991, to December 31, 1995
Authors
Discussion
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Implication
Warrants GI risk assessment before low-dose aspirin; leaves open causality and mitigation in broader populations.
Study Design
Type
Cohort (n=27,694)
Structured PICO
Does low-dose aspirin increase the risk of hospitalization for upper gastrointestinal bleeding compared to the general population?
P
Population
27,694 users of low-dose aspirin in Denmark evaluated between 1991 and 1995 for the risk of hospitalization for upper gastrointestinal bleeding compared to the general population.
E
Exposure
Low-dose aspirin (including coated and noncoated formulations)
C
Comparator
General population in the county
O
Outcome
Hospitalization for a first episode of upper gastrointestinal bleedingsafety
Main Result
Relative Risk: 2.6 (95% CI 2.2–2.9)
Low-dose aspirin use is associated with a 2.6-fold increased risk of hospitalization for upper gastrointestinal bleeding, and enteric coating does not appear to reduce this risk.
Limitations
- Observational study design
Cite This Study
Henrik Toft Sørensen (2000) reported a cohort. Low-dose aspirin vs. General population was evaluated on First episode of upper gastrointestinal bleeding with admission to the hospital (SIRR 2.6, 95% CI 2.2-2.9). Low-dose aspirin use was associated with an increased risk of hospitalization for upper gastrointestinal bleeding compared to the general population (SIRR 2.6; 95% CI 2.2-2.9).