Key result
Long-term low-dose aspirin in cardiovascular patients was associated with a 4.5% incidence of major UGIB, with risk increased by previous peptic ulcer (RR 3.1) and higher aspirin doses (RR 1.8).
Why the study?
What is the incidence and what factors influence the occurrence of upper gastrointestinal bleeding in patients taking low-dose aspirin for cardiovascular disease prevention?
Population
903 consecutive patients discharged on low-dose aspirin from the Cardiology Department of a general hospital…
Design
Cohort
Follow-up
45 +/- 22 months
Authors
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UGIB risk stratification needed before long-term low-dose aspirin in CV patients; leaves open optimal gastroprotection in high-risk subgroups.
Cohort (n=903)
No
What is the incidence and what factors influence the occurrence of upper gastrointestinal bleeding in patients taking low-dose aspirin for cardiovascular disease prevention?
In real-world cardiovascular patients, long-term low-dose aspirin carries a stable risk of major UGIB (1.2 per 100 patient-years), which is increased by higher doses and prior ulcer history, but mitigated by antisecretory drugs.
Serrano et al. (2002) conducted a cohort in Cardiovascular diseases (n=903). Low-dose aspirin was evaluated on Upper gastrointestinal bleeding (UGIB) requiring hospitalization. Long-term low-dose aspirin in cardiovascular patients was associated with a 4.5% incidence of major UGIB, with risk increased by previous peptic ulcer (RR 3.1) and higher aspirin doses (RR 1.8).
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