October 1, 2000

Glutathione depletion causes cell growth inhibition and enhanced apoptosis in pancreatic cancer cells

TSThomas SchnelldorferTufts Medical Center SGSusanne GansaugeUniversität Ulm FGFrank GansaugeShanxi University

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Abstract

Taken together, our results show enhanced GSH levels in pancreatic carcinoma and an essential role of GSH in cell proliferation and in resistance of AsPC-1 cells. Therefore, GSH-depletion may improve the efficacy of adjuvant therapy in pancreatic carcinoma.

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Schnelldorfer et al. (Sun,) studied this question.

synapsesocial.com/papers/69dcf7b25f91138675359b46 https://doi.org/https://doi.org/10.1002/1097-0142(20001001)89:7<1440::aid-cncr5>3.0.co;2-0

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