Is left atrial Endothelin-1 associated with atrial rhythm, size, and fibrosis in patients with structural heart disease?
Elevated atrial ET-1 is associated with structural and electrical remodeling in the left atrium, suggesting it may contribute to atrial fibrillation persistence.
Elevated atrial ET-1 content is associated with increased LA size, AF rhythm, hypertension, and heart failure. ET-1 is associated with atrial dilatation, fibrosis, and hypertrophy and probably contributes to AF persistence. Interventions that reduce atrial ET-1 expression and/or block its receptors may slow AF progression.
Mayyas et al. (Sat,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: