Why the study?
Is left atrial Endothelin-1 associated with atrial rhythm, size, and fibrosis in patients with structural heart disease?
Is left atrial Endothelin-1 associated with atrial rhythm, size, and fibrosis in patients with structural heart disease?
Elevated atrial ET-1 is associated with structural and electrical remodeling in the left atrium, suggesting it may contribute to atrial fibrillation persistence.
Answers are grounded in this paper and cite their sources.
May identify AF risk in structural heart disease; leaves open causal role and therapeutic targeting.
Elevated atrial ET-1 content is associated with increased LA size, AF rhythm, hypertension, and heart failure. ET-1 is associated with atrial dilatation, fibrosis, and hypertrophy and probably contributes to AF persistence. Interventions that reduce atrial ET-1 expression and/or block its receptors may slow AF progression.
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Mayyas et al. (2010) studied this question.
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