Cardiac Arrhythmias and Atrioventricular Block in a Cohort of Asymptomatic Individuals without Heart Disease

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Asymptomatic healthy individuals without heart disease (n=625). Intervention: 24-hour ambulatory electrocardiographic monitoring. Primary outcome: Frequency of atrial arrhythmias per 1-year increase in age (OR 1.059, 95% CI 1.050-1068, p=<0.0001).

Key Result

In asymptomatic healthy individuals, the frequency of atrial (OR 1.059) and ventricular arrhythmias (OR 1.023) increased with age, and transient AV block was more frequent with resting HR <60 bpm.

Study Design

Type

Cohort (n=625)

PICO

Population

Asymptomatic healthy individuals without heart disease (n=625)

Intervention / Comparator

24-hour ambulatory electrocardiographic monitoring

Primary Outcome

Frequency of atrial arrhythmias per 1-year increase in age — OR 1.059 (1.050-1068), p=<0.0001

Main Result

Effect estimate: OR 1.059 (95% CI 1.050-1068)

p-value: p=<0.0001

Abstract

AIMS: To evaluate cardiac arrhythmias and rhythm disturbances on 24 h ambulatory electrocardiographic monitoring in a cohort of asymptomatic healthy individuals with normal clinical examination. METHODS AND RESULTS: 625 asymptomatic healthy individuals, in the age range 15-83 (mean 42, SD 11.9) years; 276 (44.2%) men and 349 (55.8%) women were submitted to 24-hour ambulatory electrocardiographic monitoring. Statistical analysis was performed with likelihood ratio test and automatic backward logistic regression. The frequency of atrial arrhythmias (p < 0.0001; OR 1.059; 95% CI 1.050-1068) and of ventricular arrhythmias (p < 0.0001; OR 1.023; 95% CI 1.017-1.029) increased for each age increase of 1 year; neither atrial nor ventricular arrhythmias demonstrated a statistically significant difference relative to gender. Transient second-degree atrioventricular block (Mobitz I) was observed in 14 (2.2%) individuals and was more frequent in individuals with resting heart rate <60 bpm (p = 0.006; OR 6.7, 95% CI 1.7-25.5). CONCLUSION: The frequency of atrial and ventricular arrhythmias increased with age and did not demonstrate a significant difference relative to gender. Transient atrioventricular block was more frequent in individuals with lower resting heart rate.

Mark Helpful

Bookmark

Relay

Mark Helpful

Bookmark

Relay

Cite This Study

DePaula et al. (Fri,) conducted a cohort in Asymptomatic healthy individuals without heart disease (n=625). 24-hour ambulatory electrocardiographic monitoring was evaluated on Frequency of atrial arrhythmias per 1-year increase in age (OR 1.059, 95% CI 1.050-1068, p=<0.0001). In asymptomatic healthy individuals, the frequency of atrial (OR 1.059) and ventricular arrhythmias (OR 1.023) increased with age, and transient AV block was more frequent with resting HR <60 bpm.

synapsesocial.com/papers/6a081bc31e0fcf4a43e8a7de https://doi.org/https://doi.org/10.1159/000095950

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: