Does cardiovascular magnetic resonance (CMR) improve detection of subtle structural abnormalities in genotype positive phenotype 'negative' patients with pre-clinical hypertrophic cardiomyopathy?
CMR is being evaluated for its utility in detecting subtle structural abnormalities in pre-clinical HCM patients who appear phenotype negative by standard criteria.
To evaluate the utility of cardiovascular magnetic resonance (CMR) in detection of individuals with pathogenic/ presumed pathogenic (PA/ PP) sarcomeric mutations and gene negative patients with high clinical probability of HCM but with a negative phenotype by standard diagnostic criteria.
Deva et al. (Wed,) studied this question.