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The cellular receptor for murine thymic stromal lymphopoietin (TSLP) was detected in a variety of murine, but not human myelomonocytic cell lines by radioligand binding. cDNA clones encoding the receptor were isolated from a murine T helper cell cDNA library. TSLP receptor (TSLPR) is a member of the hematopoietin receptor family. Transfection of TSLPR cDNA resulted in only low affinity binding. Cotransfection of the interleukin 7 (IL-7)Ralpha chain cDNA resulted in conversion to high affinity binding. TSLP did not activate cells from IL-7Ralpha(-/)- mice, but did activate cells from gammac(-/)- mice. Thus, the functional TSLPR requires the IL-7Ralpha chain, but not the gammac chain for signaling.
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Linda Park
Unja Martin
Kirsten E. Garka
The Journal of Experimental Medicine
University of Washington
National Cancer Institute
Institut Pasteur
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Park et al. (Mon,) studied this question.
www.synapsesocial.com/papers/69ff952ee4618ba4162d83dc — DOI: https://doi.org/10.1084/jem.192.5.659
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