DNA Damage, Aging, and Cancer

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Abstract

This review gives an account of how the cell repairs DNA damage and presents evidence that DNA damage contributes to aging and cancer, with the outcome dependent on the type and number of lesions in DNA. Examples of accelerated aging syndromes associated with defects in DNA repair mechanisms are contrasted with cancers.

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Authors

Jan H.J. Hoeijmakers

Dartmouth College

Journals

New England Journal of Medicine

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Institutions

Erasmus University Rotterdam

Erasmus MC

Erasmus MC Cancer Institute

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Jan H.J. Hoeijmakers (Wed,) studied this question.

synapsesocial.com/papers/69dac3640d8d6ef495a3c002 — DOI: https://doi.org/10.1056/nejmra0804615

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Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity· 2009 · 138 citations
Age to survive: DNA damage and aging· 2008 · 250 citations

Also consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Lamin A/C, laminopathies and premature ageing.· 2008 · 63 citations
How Shelterin Protects Mammalian Telomeres· 2008 · 1,790 citations
Regulation of DNA double-strand break repair pathway choice· 2007 · 1,319 citations
Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity· 2009 · 138 citations
Age to survive: DNA damage and aging· 2008 · 250 citations

DNA Damage, Aging, and Cancer

Key Points

Abstract

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Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study

Also consider

Also consider