DNA Damage, Aging, and Cancer

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Abstract

This review gives an account of how the cell repairs DNA damage and presents evidence that DNA damage contributes to aging and cancer, with the outcome dependent on the type and number of lesions in DNA. Examples of accelerated aging syndromes associated with defects in DNA repair mechanisms are contrasted with cancers.

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Authors

Jan H.J. Hoeijmakers

Dartmouth College

Journals

New England Journal of Medicine

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Institutions

Erasmus University Rotterdam

Erasmus MC

Erasmus MC Cancer Institute

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DNA Damage, Aging, and Cancer

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Abstract

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