Impact of hypertension and renin–angiotensin system inhibitors in aortic stenosis

Structured PICO

Do ARBs or ACE inhibitors reduce the increased risk of mortality and stenosis progression in patients with aortic stenosis and hypertension?

Population

Patients with aortic stenosis (AS) and hypertension

Intervention

Angiotensin receptor blockers (ARBs)

Comparator

Angiotensin-converting enzyme inhibitors (ACEs)

Outcome

Mortality, stenosis progression, and incidence of clinical eventshard clinical

In patients with aortic stenosis and hypertension, ARBs, but not ACE inhibitors, appear to mitigate the increased mortality risk associated with hypertension.

Abstract

Hypertension is associated with significantly faster stenosis progression and higher incidence of clinical events in patients with AS. ARBs but not ACEs were found to abolish the increased risk of mortality associated with hypertension.

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