Does valsartan alone or combined with captopril improve survival compared to captopril in patients at high risk for cardiovascular events after myocardial infarction complicated by heart failure or left ventricular dysfunction?
Patients at high risk for cardiovascular events after myocardial infarction complicated by heart failure, left ventricular dysfunction, or both
Valsartan alone or combined with captopril
Captopril alone
Survival and cardiovascular eventshard clinical
In patients with myocardial infarction complicated by heart failure or left ventricular dysfunction, valsartan is an effective alternative to captopril, but combination therapy causes harm without added survival benefit.
Valsartan is as effective as captopril in patients who are at high risk for cardiovascular events after myocardial infarction. Combining valsartan with captopril increased the rate of adverse events without improving survival.
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Marc A. Pfeffer
John J.V. McMurray
Eric J. Velazquez
New England Journal of Medicine
Brigham and Women's Hospital
Duke Medical Center
Rigshospitalet
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Pfeffer et al. (Wed,) studied this question.
www.synapsesocial.com/papers/69d56ec075589c71d767d5c8 — DOI: https://doi.org/10.1056/nejmoa032292