Valsartan, Captopril, or Both in Myocardial Infarction Complicated by Heart Failure, Left Ventricular Dysfunction, or Both
Why the study?
Does valsartan alone or combined with captopril improve survival compared to captopril in patients at high risk for cardiovascular events after myocardial infarction complicated by heart failure or left ventricular dysfunction?
Population
Patients at high risk for cardiovascular events after myocardial infarction complicated by heart failure…
Comparison
Valsartan alone or combined with captopril vs Captopril alone
Authors
Discussion
Loading...
Member takes
Implication
Supports valsartan monotherapy as captopril alternative post-MI with HF/LV dysfunction; challenges dual blockade due to excess harm without survival gain.
Structured PICO
Does valsartan alone or combined with captopril improve survival compared to captopril in patients at high risk for cardiovascular events after myocardial infarction complicated by heart failure or left ventricular dysfunction?
P
Population
Patients at high risk for cardiovascular events after myocardial infarction complicated by heart failure, left ventricular dysfunction, or both
I
Intervention
Valsartan alone or combined with captopril
C
Comparator
Captopril alone
O
Outcome
Survival and cardiovascular eventshard clinical
In patients with myocardial infarction complicated by heart failure or left ventricular dysfunction, valsartan is an effective alternative to captopril, but combination therapy causes harm without added survival benefit.
Cite This Study
Pfeffer et al. (2003) studied this question.