July 1, 1989
View Full PaperThe predictive role of systolic, diastolic and mean blood pressures on cardiovascular and all causes of death
Structured PICO
Does systolic blood pressure predict all-cause and cardiovascular death better than diastolic or mean blood pressure in middle-aged men?
P
Population
2480 men, aged 40-59 years, belonging to three cohorts
I
Intervention
Systolic blood pressure (SBP) as a predictor
C
Comparator
Diastolic blood pressure (DBP) and mean blood pressure (MBP) as predictors
O
Outcome
All causes of death (ALL) and deaths from atherosclerotic cardiovascular disease (ACVD) at 20 years follow-uphard clinical
Systolic blood pressure is a superior predictor of all-cause and cardiovascular mortality compared to diastolic or mean blood pressure in middle-aged men.
Abstract
Systolic (SBP), diastolic (DBP) and mean MBP = diastolic + 1/3 (systolic - diastolic) blood pressures were compared as predictors of all causes of death (ALL) and of deaths from atherosclerotic cardiovascular disease (ACVD) in 2480 men, aged 40-59 years, belonging to three cohorts followed up for 20 years. Both univariate analysis, based on distribution of events in age-specific quintile classes of blood pressures, and multivariate analysis, based on the Cox proportional hazards model with five covariates as possible confounders, clearly showed the superiority of SBP over DBP in predicting fatal events; MBP played an intermediate role.