January 1, 2007Open Access

Relationship between Radial and Central Arterial Pulse Wave and Evaluation of Central Aortic Pressure Using the Radial Arterial Pulse Wave

KTKenji TakazawaAsahikawa Medical College Hospital HKHideyuki KobayashiToho University NSNaohisa ShindoTokyo Medical University

Structured PICO

Does non-invasive measurement of late systolic blood pressure in the radial artery accurately reflect changes in central aortic pressure?

Population

Patients undergoing invasive ascending aortic pressure measurement (specific demographics and sample size not stated in abstract)

Intervention

Nicorandil administration with simultaneous non-invasive radial artery pulse wave and invasive ascending aortic pressure measurement

Comparator

Baseline measurements before nicorandil administration

Outcome

Correlation between changes in maximal systolic blood pressure in the aorta and late systolic blood pressure in the radial arterysurrogate

Non-invasive measurement of late systolic blood pressure in the radial artery provides an accurate estimation of changes in central aortic pressure.

Abstract

Since a decrease of central aortic pressure contributes to the prevention of cardiovascular events, simple measurement of not only brachial blood pressure but also central aortic pressure may be useful in the prevention and treatment of cardiovascular diseases. In this study, we simultaneously measured radial artery pulse waves non-invasively and ascending aortic pressure invasively, before and after the administration of nicorandil. We then compared changes in central aortic pressure and radial arterial blood pressure calibrated with brachial blood pressure in addition to calculating the augmentation index (AI) at the aorta and radial artery. After nicorandil administration, the reduction in maximal systolic blood pressure in the aorta (Deltaa-SBP) was -14+/-15 mmHg, significantly larger than that in early systolic pressure in the radial artery (Deltar-SBP) (-9+/-12 mmHg). The reduction in late systolic blood pressure in the radial artery (Deltar-SBP2) was -15+/-14 mmHg, significantly larger than Deltar-SBP, but not significantly different from Deltaa-SBP. There were significant relationships between Deltaa-SBP and Deltar-SBP (r=0.81, p<0.001), and between Deltaa-SBP and Deltar-SBP2 (r=0.91, p<0.001). The slope of the correlation regression line with Deltar-SBP2 (0.83) was larger and closer to 1 than that with Deltar-SBP (0.63), showing that the relationship was close to 1:1. Significant correlations were obtained between aortic AI (a-AI) and radial AI (r-AI) (before nicorandil administration: r=0.91, p<0.001; after administration: r=0.70, p<0.001). These data suggest that the measurement of radial artery pulse wave and observation of changes in the late systolic blood pressure in the radial artery (r-SBP2) in addition to the ordinary measurement of brachial blood pressure may enable a more accurate evaluation of changes in maximal systolic blood pressure in the aorta (a-SBP).

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