Covalent attachment of an antipeptide to residues 633-642 of the myosin S-1 heavy chain significantly reduced its actin-binding capabilities without affecting intrinsic ATPase activities.
We have designed an "antipeptide" capable of firmly and specifically interacting with a preselected stretch of myosin S-1 heavy chain. Covalent attachment of this antipeptide to its target stretch, residues 633-642, does not affect the intrinsic ATPase activities of the protein but significantly reduces the actin-binding capabilities of the myosin head.
Chaussepied et al. (Sat,) reported a other. Antipeptide targeting residues 633-642 of myosin S-1 heavy chain vs. Control EDC-treated S-1 was evaluated on Actin-binding capabilities and ATPase activities. Covalent attachment of an antipeptide to residues 633-642 of the myosin S-1 heavy chain significantly reduced its actin-binding capabilities without affecting intrinsic ATPase activities.