Key result
Covalent attachment of an antipeptide to residues 633-642 of the myosin S-1 heavy chain significantly reduced its actin-binding capabilities without affecting intrinsic ATPase activities.
Population
Myosin S-1 heavy chain
Design
Preclinical
Authors
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Identifies myosin region for actin interaction; extends molecular insights but leaves open relevance to human cardiac disease.
The stretch of residues 633-642 of the myosin heavy chain is identified as part of the actin-binding site.
Chaussepied et al. (1988) studied this question. Antipeptide targeting residues 633-642 of myosin S-1 heavy chain vs. Control EDC-treated S-1 was evaluated on Actin-binding capabilities and ATPase activities. Covalent attachment of an antipeptide to residues 633-642 of the myosin S-1 heavy chain significantly reduced its actin-binding capabilities without affecting intrinsic ATPase activities.
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