Cardiac steatosis is an early manifestation in the pathogenesis of type 2 diabetes mellitus, occurring before the onset of heart failure.
In humans, impaired glucose tolerance is accompanied by cardiac steatosis, which precedes the onset of type 2 diabetes mellitus and left ventricular systolic dysfunction. Thus, lipid overstorage in human cardiac myocytes is an early manifestation in the pathogenesis of type 2 diabetes mellitus and is evident in the absence of heart failure.
McGavock et al. (Tue,) studied this question.