Key result
Cardiac steatosis emerges during impaired glucose tolerance, preceding type 2 diabetes and left ventricular systolic dysfunction.
Why the study?
Impaired glucose tolerance is accompanied by cardiac steatosis, which precedes type 2 diabetes mellitus and left ventricular systolic dysfunction, but its early role is not fully characterized.
Population
Humans with impaired glucose tolerance
Design
Other
Authors
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May signal early cardiac involvement in T2DM; leaves open causal role and need for prospective studies.
Cardiac steatosis is an early manifestation in the pathogenesis of type 2 diabetes mellitus, occurring before the onset of heart failure.
McGavock et al. (2007) studied this question. Cardiac steatosis accompanies impaired glucose tolerance, preceding the onset of type 2 diabetes and left ventricular systolic dysfunction even in the absence of heart failure.
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