Diffusion tensor MRI accurately mapped the fibrous architecture of formalin-fixed rabbit hearts, with fiber orientations differing from histology by an average of 3.7 degrees.
Diffusion tensor MRI is emerging as a rapid, nondestructive method to map myocardial fiber organization. It accurately measures myofiber orientation in hearts bathed in or perfused with cardioplegic solution. This study shows it also accurately maps the fibrous architecture of formalin-fixed hearts. Fiber orientations obtained by MRI and histology at the same locations in an excised portion of rabbit ventricle differed on average by 3.7 degrees (SD = 6.4 degrees, N = 70), a closer correspondence than achieved with previous preparations. The longer acquisition times afforded by fixed-heart imaging provides better accuracy, and should enable high-resolution reconstruction of the entire ventricular architecture. Magn Reson Med 44:157-161, 2000.
Holmes et al. (Sat,) conducted a other in Myocardial fiber organization. Diffusion tensor MRI vs. Histology was evaluated on Difference in fiber orientation between MRI and histology. Diffusion tensor MRI accurately mapped the fibrous architecture of formalin-fixed rabbit hearts, with fiber orientations differing from histology by an average of 3.7 degrees.
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