Key result
Diffusion tensor MRI accurately mapped the fibrous architecture of formalin-fixed rabbit hearts, with fiber orientations differing from histology by an average of 3.7 degrees.
Why the study?
Does diffusion tensor MRI accurately map myofiber orientation in formalin-fixed rabbit myocardium compared to histology?
Does diffusion tensor MRI accurately map myofiber orientation in formalin-fixed rabbit myocardium compared to histology?
Diffusion tensor MRI provides accurate mapping of myocardial fiber organization in formalin-fixed hearts, closely matching histological measurements.
Answers are grounded in this paper and cite their sources.
Supports ex vivo validation of diffusion tensor MRI in rabbit hearts; leaves open translation to in vivo human applications.
Diffusion tensor MRI is emerging as a rapid, nondestructive method to map myocardial fiber organization. It accurately measures myofiber orientation in hearts bathed in or perfused with cardioplegic solution. This study shows it also accurately maps the fibrous architecture of formalin-fixed hearts. Fiber orientations obtained by MRI and histology at the same locations in an excised portion of rabbit ventricle differed on average by 3.7 degrees (SD = 6.4 degrees, N = 70), a closer correspondence than achieved with previous preparations. The longer acquisition times afforded by fixed-heart imaging provides better accuracy, and should enable high-resolution reconstruction of the entire ventricular architecture. Magn Reson Med 44:157-161, 2000.
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Holmes et al. (2000) studied Myocardial fiber organization. Diffusion tensor MRI vs. Histology was evaluated on Difference in fiber orientation between MRI and histology. Diffusion tensor MRI accurately mapped the fibrous architecture of formalin-fixed rabbit hearts, with fiber orientations differing from histology by an average of 3.7 degrees.
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