Extensive arterial vascular adaptations, including diameter decrease and enhanced flow-mediated dilation, occur within 3-8 weeks of inactivity in humans.
Observational
What are the magnitude and time course of arterial vascular adaptations to 3-8 weeks of inactivity in humans?
Inactivity for 3-8 weeks leads to significant arterial vascular adaptations, including decreased diameter and enhanced flow-mediated dilation, indicating that inactivity adaptations are not simply the inverse of exercise adaptations.
We demonstrate that extensive arterial vascular adaptations occur within 3-8 wk of inactivity in humans. We put forth the hypothesis that the diameter decrease represents an adaptation to a lack of variation in peak shear stress. Furthermore, an enhanced flow-mediated dilation in deconditioned arteries implies that functional vascular adaptations to inactivity are not simply the inverse of adaptations to exercise.
Groot et al. (Sat,) conducted a observational in Inactivity. Inactivity was evaluated on Arterial vascular adaptations (diameter decrease and flow-mediated dilation). Extensive arterial vascular adaptations, including diameter decrease and enhanced flow-mediated dilation, occur within 3-8 weeks of inactivity in humans.